Kavanna Jade Trust
Kavannas illness Chronic suppurative lung disease, or CSLD, is used to describe a range of lung diseases characterised by a chronic wet cough and progressive lung damage. We are interested in the non-cystic fibrosis forms of the disease with a focus on bronchiectasis – the severe form of CSLD.
Bronchiectasis is a disease where the bronchi (the branches going into the lung) become permanently damaged. CSLD and bronchiectasis may be diagnosed in adults and children. Some adults diagnosed with the disease have had symptoms since childhood.
What is currently known about the causes of chronic suppurative lung disease?
Surprisingly, very little. For a long time, pediatric CSLD and bronchiectasis have been considered “orphan” diseases as there has been little research in this field. We know that severe pneumonia in early life is a CSLD risk factor. It’s thought that conditions in the lung following severe pneumonia help establish a long-term lower airway infection. The body responds to this with an inflammatory response which can also cause damage to the lung. If the infections aren’t treated or well managed the lung tissue may continue to be damaged. This can lead to loss of lung function and subsequent reduction in life-expectancy.
In terms of CSLD microbiology, we know from culture-based studies that several different bacteria may be present in lung washes of children with CSLD. DNA-based studies of other lower airway diseases have also shown that the bacteriology of chronic respiratory infections may be more complex than previously thought. We’re not sure if interactions between different bacteria and viruses may contribute to the disease pathogenesis, acute exacerbations or therapeutic effectiveness. This information is needed to provide an evidence base for future clinical management strategies. ”
(Dr. Robyn Marsh, Menzies School of Health Research)
Chronic suppurative lung disease, or CSLD
We are interested in the non-cystic fibrosis forms of the disease with a focus on bronchiectasis – the severe form of CSLD.